業績

論文

2012

2011

Miyagaki Y, Kanemori Y, Baba T.
Possible involvement of mitogen- and stress-activated protein kinase 1, MSK1, in
metaphase-ll arrest through phosphorylation of EMI2 in mouse oocytes.
Dev Biol. 2011 Nov 1;359(1):73-81. Epub 2011 Sep 5.

2010

Okada K, Kimura M, Moriyama Y, Nakai M, Kikuchi K, Kaneko H, Kunieda T, Baba T, Noguchi J.
Expression analysis of MIF4GD in the rat testis.
J. Reprod Dev. 2010 Dec 9. [Epub ahead of print]

Kawano N, Kang W, Yamashita M, Koga Y, Yamazaki T, Hata T, Miyado K, Baba T.
Mice Lacking Two Sperm Serine Proteases, ACR and PRSS21, Are Subfertile, but the Mutant Sperm Are Infertile In Vitro.
Biol. Reprod., 83: 359-369, 2010.

Akama K, Horikoshi T, Sugiyama A, Nakahata S, Akitsu A, Niwa N, Intoh A, Kakui Y, Sugaya M, Takei K, Imaizumi N, Sato T, Matsumoto R, Iwahashi H, Kashiwabara S, Baba T, Nakamura M, Toda T.
Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme.
Biochim. Biophys. Acta., 1804: 1272-1284, 2010.

Kang, W., Zhou, C., Koga, Y., and Baba, T.
Hyaluronan-degrading activity of mouse sperm hyaluronidase is not required for fertilization?
J. Reprod. Dev., 56:140-144, 2010.

2009

Kimura, M., Kim, E., Kang, W., Yamashita, M., Saigo, M., Yamazaki, T., Nakanishi, T., Kashiwabara, S., and Baba, T.
Functional roles of sperm hyaluronidases, HYAL5 and SPAM1, in fertilization of the mouse.
Biol. Reprod., 81: 939-947, 2009.

Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S., Baba, T., and Suzuki, T.
Selective stabilization of mammalian microRNAs by 3'-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2.
Genes Dev., 23: 433-438, 2009.

Klajn, A., Ferrai, C., Stucchi, L., Prada, I., Podini, P., Baba, T., Rocchi, M., Meldolesi, J., and D'Alessandro, R.
The REST repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex.
J. Neurosci., 29: 6296-6307, 2009.

Kimura, M., Ishida, K., Kashiwabara, S., and Baba, T.
Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.
Biol. Reprod., 80: 545-554, 2009.

2008

Kashiwabara, S., Nakanishi, T., Kimura, M., and Baba, T.
Non-canonical poly(A) polymerase in mammalian gametogenesis. Biochim. Biophys.
Acta-Gene Structure Expression, 1779: 230-238, 2008.

Kim, E., Yamashita, M., Kimura, M., Honda, A., Kashiwabara, S., and Baba, T
Sperm penetration through cumulus mass and zona pellucida.
Int. J. Dev. Biol., 52: 677-682, 2008.

Nakanishi, T., Ishibashi, N., Kubota, H., Inoue, K., Ogonuki, N., Ogura, A., Kashiwabara, S., and Baba, T.
Birth of normal offspring from mouse eggs activated by a phospholipase Czeta protein lacking three EF-hand domains.
J. Reprod. Dev., 54: 244-249, 2008.

Yamashita, M., Honda, A., Ogura, A., Kashiwabara, S., Fukami, K., and Baba, T
Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment.
Genes Cells, 13: 1001-1013, 2008.

Hara, Y., Yamagata, K., Oguchi, K., and Baba, T.
Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis.
FEBS Lett., 582: 2998-3004, 2008.

2007

Yamazaki, T., Yamagata, K., and Baba, T.
Time-lapse and retrospective analysis of DNA methylation in mouse preimplantation embryos by live cell imaging.
Dev. Biol., 304: 409-419, 2007.

Yamashita, M., Yamagata, K., Tsumura, K., Nakanishi, T., and Baba, T
Acrosome reaction of mouse epididymal sperm on oocyte zona pellucida.
J. Reprod. Dev., 53: 255-262, 2007.

Yamazaki, T., Kobayakawa, S., Yamagata, K., Abe, K., and Baba, T.
Molecular dynamics of heterochromatin protein 1beta, HP1beta, during mouse preimplantation development.
J. Reprod. Dev., 53: 1035-1041, 2007.

Yamagata, K., Yamazaki, T., Miki, H., Ogonuki, N., Inoue, K., Ogura, A., and Baba, T
Centromeric DNA hypomethylation as epigenetic signature for germline.
Dev. Biol., 312: 419-426, 2007.

Nakanishi, T., Kumagai, S., Kimura, M., Watanabe, H., Sakurai, T., Kimura, M., Kashiwabara, S., and Baba, T
Disruption of mouse poly(A) polymerase mGld-2 does not alter polyadenylation status in oocytes and somatic cells.
Biochem. Biophys. Res. Commun., 364: 14-19, 2007.

2006

Nakanishi, T., Kubota, H., Ishibashi, N., Kumagai, S., Watanabe, H., Yamashita, M., Kashiwabara, S., Miyado, K., and Baba, T.
Possible role of mouse poly(A) polymerase mGLD-2 during oocyte maturation.
Dev. Biol., 289: 115-126, 2006.

Kim, E., Yamashita, M., Nakanishi, T., Park, K. -E., Kimura, M., Kashiwabara, S., and Baba, T
Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization.
J. Biol. Chem., 281: 5634-5639, 2006.

Murayama, A., Sakura, K., Nakama, M., Yasuzawa-Tanaka, K., Fujita, E., Tateishi, Y., Wang, Y., Ushijima, T., Baba, T., Shibuya, K., Shibuya, A., Kawabe, Y., and Yanagisawa, J.
A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory.
EMBO J., 25: 1081-1092, 2006.

Miki, H., Ogonuki, N., Inoue, K., Baba, T., and Ogura, A.
Improvement of cumulus-free oocyte maturation in vitro and its application to microinsemination with primary spermatocytes in mice.
J. Reprod. Dev., 52: 239-248, 2006.

Ito, M., Miyagishi, M., Murata, C., Kawasaki, H., Baba, T., Tachi, C., and Taira, K
Down-regulation of endogenous Wt1 expression by Sry transgene in murine embryonic mesonephros-derived M15 cell line.
J. Reprod. Dev., 52: 415-427, 2006.

Iwase, S., Shono, N., Honda, A., Nakanishi, T., Kashiwabara, S., Takahashi, S., and Baba, T.
A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice.
FEBS Lett., 580: 3129-3135, 2006.

2005

Shi, Y. -J., Matson, C., Lan, F., Iwase, S., Baba, T., and Shi, Y.
Regulation of LSD1 histone demethylase activity by its associated factors.
Mol. Cell, 19: 857-864, 2005.

Kim, E., Baba, D., Kimura, M., Yamashita, M., Kashiwabara, S., and Baba, T
Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.
Proc. Acad. Natl. Sci. USA, 102: 18028-18033, 2005.

Tanaka, H., and Baba, T.
Gene expression in spermiogenesis.
Cell. Mol. Life Sci., 62: 344-354, 2005.

Dube, C., Leclerc, P., Baba, T., Reyes-Moreno, C., and Bailey, J. L.
The proacrosin-binding protein, sp32, is tyrosine phosphorylated during capacitation of pig sperm.
J. Androl., 26: 519-528, 2005.

Miki, H., Inoue, K., Kohda, T., Honda, A., Ogonuki, N., Yuzuriha, M., Mise, N., Matsui, Y., Baba, T., Abe, K., Ishino, F., and Ogura, A.
Birth of mice produced by germ cell nuclear transfer.
Genesis, 41: 81-86, 2005.

Hara, M., Sata, T., Kikuchi, T., Nakajima, N., Uda, A., Fujimoto, K., Baba, T., and Mukai, R.
Isolation and characterization of a new simian retrovirus type D subtype from monkeys at the Tsukuba Primate Center, Japan.
Microbes Infect., 7: 126-131, 2005

Hara, M., Kikuchi, T., Ono, F., Takano, J., Ageyama, N., Fujimoto, K., Terao, K., Baba, T., and Mukai, R.
Survey of captive cynomolgus macaque colonies for SRV/D infection by using polymerase chain reaction assays.
Comp. Med., 55: 145-149, 2005.

2004

Nishimura, H., Kim, E., Nakanishi, T., and Baba, T.
Possible function of the ADAM1a/ADAM2 fertilin complex in the appearance of ADAM3 on the sperm surface.
J. Biol. Chem., 279: 34957-34962, 2004.

Zhuang, T., Kashiwabara, S., Noguchi, J., and Baba, T.
Transgenic expression of testis-specific poly(A) polymerase TPAP in wild-type and TPAP-deficient mice.
J. Reprod. Dev., 50: 207-213, 2004.

Onuki, R., Bando, Y., Suyama, E., Katayama, T., Kawasaki, H., Baba, T., Tohyama, M., and Taira, K.
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease.
EMBO J., 23: 959-968, 2004.

Fukuzawa, N. H., Ohsako, S., Wu, Q., Sakaue, M., Fujii-Kuriyama, Y., Baba, T., and Tohyama, C.
Testicular cytochrome P450sec and LHR as possible targets of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) in the mouse.
Mol. Cell. Endocrinol., 221: 87-96, 2004.

Nakanishi, T., Isotani, A., Yamaguchi, R., Ikawa, M., Baba, T., Suarez, S. S., and Okabe, M.
Selective passage through the uterotubal junction of sperm from a mixed population produced by chimeras of calmegin-knockout and wild-type male mice.
Biol. Reprod., 71: 959-965, 2004.

Kim, E., Nishimura, H., Iwase, S., Yamagata, K., Kashiwabara, S., and Baba, T.
Synthesis, processing, and subcellular localization of mouse ADAM3 during spermatogenesis and epididymal sperm transport.
J. Reprod. Dev., 50: 571-578, 2004.

Miki, H., Inoue, K., Ogonuki, N., Mochida, K., Nagashima, H., Baba, T., and Ogura, A.
Cytoplasmic asters are required for progression past the first cell cycle in cloned mouse embryos.
Biol. Reprod., 71: 2022-2028, 2004.

Tateishi, Y., Kawabe, Y., Chiba, T., Murata, S., Ichikawa, K., Murayama, A., Tanaka, K., Baba, T., Kato, S., and Yanagisawa, J.
Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor.
EMBO J., 23: 4813-4823, 2004.

Iwase, S., Januma, A., Miyamoto, K., Shono, N., Honda, A., Yanagisawa, J., and Baba, T.
Charcaterization of BHC80 in BRAF-HDAC complex involved in neuron-specific gene repression.
Biochem. Biophys. Res. Commun., 322: 601-608, 2004.

2003

Sugiura, S., Kashiwabara, S., Iwase, S., and Baba, T.
Expression of a testis-specific form of TBP-related factor 2 (TRF2) mRNA during mouse spermatogenesis.
J. Reprod. Dev., 49: 107-111, 2003.

Doi, H., Baba, T., Tohyama, C., and Nohara, K.
Functional activation of arylhydrocarbon receptor (AhR) in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Chemosphere, 52: 655-662, 2003.

Fukuzawa, N. H., Ohsako, S., Nagano, R., Sakaue, M., Baba, T., Aoki, Y., and Tohyama, C.
Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Toxicol.
In Vitro, 17: 259-269, 2003.

Kim, E., Nishimura, H., and Baba, T.
Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
Biochem. Biophys. Res. Commun., 304: 313-319, 2003.

Fujita, T., Kobayashi, Y, Wada, O., Tateishi, Y., Kitada, L., Yamamoto, Y., Takashima, H., Murayama, A., Yano, T., Baba, T., Kato, S., Kawabe, Y., and Yanagisawa, J.
Full activation of estrogen receptor α activation function-1 induces proliferation of breast cancer cells.
J. Biol. Chem., 278: 26704-26714, 2003.

2002

Baba, D., Kashiwabara, S., Honda, A., Yamagata, K., Wu, Q., Ikawa, M., Okabe, M., and Baba, T.
Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg.
J. Biol. Chem., 277: 30310-30314, 2002.

Honda, A., Yamagata, K., Sugiura, S., Watanabe, K., and Baba, T.
A mouse serine protease TESP5 is selectively included into lipid rafts of sperm membrane presumably as a glycosylphosphatidylinositol-anchored protein.
J. Biol. Chem., 277: 16976-16984, 2002.

Takahashi, Y., Kako, K., Kashiwabara, S., Takehara, A., Inada, Y., Arai, H., Nakada, K., Kodama, H., Hayashi, J., Baba, T., and Munekata, E.
Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome c oxidase and embryonic development.
Mol. Cell Biol., 22: 7614-7621, 2002.

Kashiwabara, S., Noguchi, J., Zhuang, T., Ohmura, K., Honda, A., Sugiura, S., Miyamoto, K., Takahashi, S., Inoue, K., Ogura, A., and Baba, T.
Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP.
Science, 298: 1999-2002, 2002.

He, Q. -C., Zhou, J. -M., Zhou, D. -M., Nakamatsu, Y., Baba, T., and Taira, K.
Comparison of metal-ion-dependent cleavages of RNA by a DNA enzyme and a hammerhead ribozyme.
Biomacromolecules, 3: 69-83, 2002.

Nishimura, H., Kim, E., Fujimori, T., Kashiwabara, S., Kuroiwa, A., Matsuda, Y., and Baba, T.
The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin α) gene, are localized on mouse chromosome 5.
Gene, 291: 67-76, 2002.

Kodama, E., Baba, T., Kohno, N., Satoh, S., Yokosawa, H., and Sawada, H.
Spermosin, a trypsin-like protease from ascidian sperm: cDNA cloning, protein structures and functional analysis.
Eur. J. Biochem., 269: 657-663, 2002.

Zhou, J. -M., Fujita, S., Warashina, M., Baba, T., and Taira, K.
A novel strategy by the action of ricin that connects phenotype and genotype without loss of the diversity of libraries.
J. Am. Chem. Soc., 124: 538-543, 2002.

Siruntawineti, J., Yamagata, K., Nakanishi, T., and Baba, T.
Occurrence of small, round vesicles in the acrosome of elongating spermatids from a mouse mutant line with a partial deletion of the Y chromosome.
J. Reprod. Dev., 48: 513-521, 2002.

Wu, Q., Ohsako, S., Baba, T., Miyamoto, K., and Tohyama, S.
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on preimplantation mouse embryos.
Toxicol., 174: 119-129, 2002.

Honda, A., Sirundawineti, J., and Baba, T.
Role of acrosomal matrix proteases in sperm-zona pellucida interactions.
Hum. Reprod. Update, 8: 405-412, 2002.

Zhou, J. -M., Zhou, D. -M., Takagi, Y., Kasai, Y., Inoue, A., Baba, T., and Taira, K.
Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme.
Nuc. Acids Res., 30: 2374-2382, 2002.

Onuki, R., Nagasaki, A., Kawasaki, H., Baba, T., Uyeda, T. Q., and Taira, K.
Confirmation by FRET in individual living cells of the absence of significant amyloid β-mediated caspase 8 activation. Proc.
Natl. Acad. Sci. USA, 99: 14716-14721, 2002.

2001

Kodama, E., Baba, T., Yokosawa, H., and Sawada, H.
cDNA cloning and functional analysis of ascidian sperm proacrosin.
J. Biol. Chem., 276: 24594-24600, 2001.

Murata, T., Nagaso, H., Kashiwabara, S., Baba, T., Okano, H., and Yokoyama, K.
The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster.
Dev. Biol., 233: 137-147, 2001.

Mizuno, K., Kobayashi, E., Tachibana, M., Kawasaki, T., Fujimura, T., Funane, K., Kobayashi, M., and Baba, T.
Characterization of an isoform of rice starch branching enzyme, RBE4, in developing seeds.
Plant Cell Physiol., 42: 349-357, 2001.

Nishimura, H., Gogami, A., Miyagawa, Y., Nanbo, A., Murakami, Y., Baba, T., and Nagasawa, S.
Bactericidal/permeability-increasing protein promotes complement activation for neutrophil-mediated phagocytosis on bacterial surface.
Immunology, 103: 519-525, 2001.

Takahashi, Y., Kako, K., Ohmura, K., Tsumori, K., Ohmasa, Y., Kashiwabara, S., Baba, T., and Munekata, E.
Genomic structure of mouse copper chaperone, COX17.
DNA Sequence, 12: 305-318, 2001.

2000

Inoue, A., Ishiji, A., Kasagi, S., Ishizuka, M., Hirose, S., Baba, T., and Hagiwara, H.
The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis.
Biochem. Biophys. Res. Commun., 273: 398-403, 2000.

Yamamoto, R., Katahira, M., Nishikawa, S., Baba, T., Taira, K., and Kumar, P. K. R.
A novel RNA motif that binds efficiently and specifically to the Tat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo.
Genes to Cells, 5: 371-388, 2000.

Yamamoto, R., Baba, T., and Kumar, P. K. R.
Molecular beacon aptamer fluoresces in the presence of Tat protein of HIV-1.
Genes to Cells, 5: 389-396, 2000.

Mori, T., Guo, M. W., Sato, E., Baba, T., Takasaki, S., and Mori, E.
Molecular and immunological approaches to mammalian fertilization.
J. Reprod. Immunol., 47: 139-158, 2000.

Kashiwabara, S., Zhuang, T., Yamagata, K., Noguchi, J., Fukamizu, A., and Baba, T.
Identification of a novel isoform of poly(A) polymerase, TPAP, specifically present in the cytoplasm of spermatogenic cells.
Dev. Biol., 228: 106-115, 2000.

研究費獲得状況

文部科学省科学研究費（平成２１年度～２５年度）
　新学術領域研究「動植物のアロ認証」（計画研究）　
　　　　　　　　　哺乳類の雌性生殖器における精子認証機構の解明

文部科学省科学研究費（平成２１年度～２４年度）
　基盤研究（Ａ）　受精と着床に関する基礎研究と応用基盤の構築

文部科学省科学研究費（平成２１年度～２２年度）
　特定領域研究　　雌性生殖器での受精制御機構と世代サイクル維持

文部科学省科学研究費（平成１８年度～２１年度）
　基盤研究（Ａ）　雌性生殖器での精子機能制御の仕組み

文部科学省科学研究費（平成１９年度～２０年度）
　特定領域研究　　精子GPIアンカーセリンプロテアーゼTESP5による細胞機能制御

文部科学省科学研究費（平成１８年度～１９年度）
　萌芽研究　　　　体細胞での精巣特異的遺伝子転写の抑制破綻と癌化

文部科学省科学研究費（平成１８年度～１９年度）
　特定領域研究　　子宮の細胞外環境と精子機能制御

文部科学省科学研究費（平成１５年度～１８年度）
　基盤研究（Ａ）　雄性配偶子の「なりたち」と「はたらき」の分子基盤

文部科学省科学研究費（平成１５年度～１６年度）
　萌芽研究　　　　精子形成過程での細胞質ｍＲＮＡポリＡ鎖伸長制御の意義に関する研究

文部科学省科学研究費（平成１１年度～１５年度）
　特定領域研究　　雄性配偶子の異種細胞間相互作用による機能制御の分子機構

文部科学省科学研究費（平成１２年度～１４年度）
　基盤研究（Ａ）　受精と胚子発生の制御機構に関する発生工学的研究

文部科学省科学研究費（平成１３年度～１４年度）
　萌芽研究　　　　精子細胞膜マイクロドメインの解析による精子と卵の相互作用に関する
　　　　　　　　　新しい理論構築